Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?
نویسندگان
چکیده
منابع مشابه
Real-world evidence: How pragmatic are randomized controlled trials labeled as pragmatic?
INTRODUCTION Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines. Explanatory and pragmatic are the extremes of a continuum. This d...
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ژورنال
عنوان ژورنال: BMC Medicine
سال: 2018
ISSN: 1741-7015
DOI: 10.1186/s12916-018-1038-2